What is a "slimming pen"? Can you really make it thin?
Obesity can lead to various diseases in diseases such as diabetes, disease, high blood cholesterol disease pressure, hypertension, coronary heart disease. As well as increase the risk of developing cancer in the future
In addition to diet , exercise and lifestyle and medication to lose weight is another approach that is popular for those who do not have time to exercise , but the effect is to make rapid heartbeat, insomnia, restlessness, hallucinations, drug addiction and back fat is repeated.
There is now another option, a subcutaneous slimming pen . In conjunction with diet and exercise, it was found that more than 10% or at least 5% of weight was reduced in the trial group and the subjects' waist circumference decreased by 8.2 cm in the first 2 months.
Obesity is an unpleasant thing for many people. Especially women Because if you are overweight, you may lose your personality. Lack of confidence Some people may suffer from depression, which is why obese people try to find methods such as taking weight loss courses. Slimming Injections to dissolve excess fat, liposuction, surgery to reduce belly and waist size. Gastric bypass surgery Including the use of various weight loss drugs, such as brain hunger pills Drugs to inhibit fat digestion enzymes, etc.
How is it considered "fat"?
Dr. Jitkae Thepchatree, MD. Anti-aging and Rehabilitation Medicine Samitivej Sukhumvit Hospital states that "obesity" or "obesity" can be found from the body mass index (BMI), which is calculated from body weight and height (click To find your body mass index), which can be interpreted as follows
| BMI ASEAN Standard (Asia) | Interpretation of results |
| <18.5 | <18.5 | Weight less than standard |
| 18.5-24.9 | 18.5-22.9 | normal |
| 25-29.9 | 23-24.9 | Obesity Level 1 |
| 30-34.9 | 25-29.9 | Obesity Level 2 |
| 35-39.9 | Greater than or equal to 30 | Obesity Level 3 |
| Greater than or equal to 40 | - | Obesity Level 4 |
"Overweight" risk of death
People who are overweight There will be more adipose tissue in the body and inserted by internal organs. Causing the work of various systems to be abnormal until various diseases such as
- Diabetes mellitus type 2 (the Type 2 Diabetes ) due to chronic inflammation of fat cells will interfere. "Insulin hormone" created from the pancreas. (Controls the sugar level in the body), resulting in insulin resistance. Causing high levels of insulin in the blood Which will stop the breakdown of fat As a result, there is an increase in fat accumulation, the belly becomes bigger, and the future threat is diabetes and obesity.
- Hyperlipidemia (Dyslipidemia ) with dyslipidemia in obesity. Will result in triglyceride levels (Triglyceride) and free fatty acid (Free fatty acid) and lipoprotein type B (ApoB) increase, resulting in inflammation of the arteries leading to cardiovascular disease later.
- Cardiovascular disease when there is a high blood sugar level or high blood fat Causing blood vessels to become inflamed or narrowed The flexibility of the arteries as a result of the pressure, hypertension, heart work harder to pump blood. Faster heartbeat Increased risk of death from ischemic heart disease and ischemic stroke or ruptured.
- Chronic obesity This is because excess fat cells stimulate the body to produce a kind of inflammatory chemical, C-RP (C-Reactive Protein). C-RP binds to the hormone “leptin”, a hormone that acts. Tell them to know that they are full and formed a large C-RP Leptin Complex. Cannot pass the cortex This causes resistance to the hormone "leptin"
if there are too many fat cells. Leptin hormone or satiety hormone The more it builds up, the more the body becomes more resistant to leptin, which makes it harder for you to eat more. - Cancer It was found that about 25-30% of cancer of the colon, breast (menopause), endometrium. (endometrium) kidney and esophagus Caused by obesity and lack of physical exertion And only 5-10% of your original weight loss will improve your health .
It could be said that obesity is the leading cause of diseases such as diabetes , hyperlipidemia. Hypertension Coronary heart disease As well as increasing the risk of developing cancer in the future
Current diet pills
Besides diet, exercise, and lifestyle changes that are at risk of obesity. Many people turn to drugs. Because there is no time to take care of yourself Or need a shortcut such as brain hunger However, it was found that the negative effect of anti- obesity drug in the brain suppression group. Causing you to not want to eat Will cause the heart to beat faster, squeeze, increase blood pressure Respiratory disturbance, insomnia, anxiety, hallucinations, drug addiction and yo-yo or come back to fat again.
Slimming pen Helping people really are obese?
No one would think that A journalist on the show about the Gila monster, a chameleon native to southern America and can be found in deserts in many countries. Will be bitten until there is hepatitis Nausea and vomiting led to the discovery that Chameleon saliva contains Exendin-4 that has chemical properties similar to human GLP-1 or a group of gut hormones that have hypoglycemic activity. In the early stages it developed into a drug for diabetics. Which has the ability to regulate blood sugar levels without causing the sugar to drop or flash Can reduce the accumulated sugar or HbA1C in people who like to eat sweet often. And the weight of diabetic patients with obesity decreased by at least 10%.
And in 2014, the US Food and Drug Administration approved a new drug called liraglutide as a subcutaneous injection, administered once a day. It is used for weight loss along with diet and exercise. According to clinical studies, treatment with liraglutide 3.0 mg was able to reduce body weight in patients with a BMI greater than 30 kg / m2 (obesity) in both diabetes and diabetes mellitus. Not diabetic And in patients with a BMI of 27 kg / m 2 (overweight) with diseases or disorders related to weight gain such as hypertension, diabetes and abnormal blood lipids. For example, after 20 weeks, the most common adverse reactions occurred in the gastrointestinal tract such as nausea, vomiting, loss of appetite, which made the drug-fed less likely. Without affecting the brain's activity or causing drug addiction in any way
Inside the pen weight-loss indication.
The drug liraglutide is developed as a pen with a very fine needle. To inject the stomach The patient's thigh or upper arm For long term weight loss The trial compared with placebo in 3,731 volunteers who did not have diabetes. And a body mass index greater than 30 kg / sq m (obesity) and in people with a body mass index of 27 kg / sq m (overweight) with disease or disorders associated with Weight gain, such as high blood pressure, diabetes, and abnormal blood fat. After the 56-week trial, it was found that the weight of the subjects who received the drug decreased by more than 10% or at least 5% during the first 2 months, and the subjects' waist circumference decreased by 8.2 cm. It was found that the drug resulted in a weight gain of only 1.9%.
Mechanism of drug action
This drug is similar to the hormone glucagon (Glucagon) in the body after it enters the bloodstream.
- Send signals to reduce appetite to the brain. Make you less hungry
- Reduce the compression of the stomach Helping food stay in the stomach for longer So you can eat less food
- Stimulate the pancreas to release the hormone insulin to help balance blood sugar levels. Without causing the sugar to fall or flash Because the drug will only work when we have eaten food
Some of the adverse reactions are nausea, vomiting, loss of appetite, abdominal pain, diarrhea, or constipation, but not everyone. And drug users will be able to adjust to the drug after 1 week
Contraindications For those with a family history of thyroid cancer, thyroid disease, children under 18 years of age, people with pancreatitis. People who are pregnant or breastfeeding, the elderly, who are taking certain diabetes drugs. People with liver or kidney disease
However, a slimming pen is just one way to help lose weight. Above all, diet Eat only what is wholesome Exercise regularly Getting enough sleep, not staying up late, or stressing out stress will help you to achieve your weight loss goals faster.
To lose weight that will be successful. We should first understand our bodies from the inside that What are the real causes of the disorder? Sometimes, incorrect diet and exercise. It can lead to failure and abandonment.
